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doi: 10.3389/fncel.2020.581191 Received 08 July 2020 Accepted 30 November 2020 Published 23 December 2020 Volume 14 - 2020 Edited by John Zhang, Loma Linda University, United States Reviewed by Hermona Soreq, Hebrew University of Jerusalem, Israel

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Current preclinical and clinical data that supports the effectiveness of polyphenols in reducing the advancement of diseases, boosting cognitive abilities, and promoting overall brain health ( 2 Polyphenols pharmacological function to protect neuroinflammation and neurodegenerative diseases Neuroinflammation is a pathological process that involves the activation of glial cells and the subsequent production of pro-inflammatory cytokines, resulting in neuronal damage and impaired functionality (Figure 2) (Table 1 is a representation of the pharmacological function of polyphenols under different neurodegenerative diseases

These cells are also specialized to recognize bacterial-derived molecules, known as prokaryotic-associated molecular patterns, with the help of the Toll-like receptors on the cell surface and the nucleotide-binding oligomerization domain-like receptors in the cytoplasm, which activate defense mechanisms by the secretion of anti-microbial peptides 2